Differential Target Gene Activation by the Staphylococcus aureus Two-Component System saeRS
نویسندگان
چکیده
منابع مشابه
The SaeRS Two-Component System of Staphylococcus aureus
In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS twocomponent system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases. The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ. Since...
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The SaeRS two-component system plays important roles in regulation of key virulence factors and pathogenicity. In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementation of the mutant with SaeRS returned survival to wild-type levels. Moreover, these phenomena were observed in different MRSA genetic background isolates...
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Calprotectin, the most abundant cytoplasmic protein in neutrophils, suppresses the growth of Staphylococcus aureus by sequestering the nutrient metal ions Zn and Mn. Here we show that calprotectin can also enhance the activity of the SaeRS two component system (TCS), a signaling system essential for production of over 20 virulence factors in S. aureus. The activity of the SaeRS TCS is repressed...
متن کاملDifferential activation of Staphylococcus aureus
3 Catherine A. Wakeman, Devin L. Stauff, Yaofang Zhang, and Eric P. Skaar 4 5 6 7 8 9 10 11 1 Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 12 Nashville, TN, USA 37232, 2 Current address: Department of Biology, Grove City College, Grove City, 13 Pennsylvania, USA 16127 14 Running title: Toxic heme analogues activate S. aureus HssRS/HrtAB 15 16
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Staphylococcus epidermidis, which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two-component signal transduction system SaeRS. In this study, we performed a proteomic analysis of differences in expression between the S. epidermidis 1457 wild-type and saeRS mutant to identify candidates regulated by saeRS using two-dime...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2010
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.01242-09